Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma
نویسندگان
چکیده
منابع مشابه
[Expression of nuclear Ki-67 antigen in prostatic high grade intraepithelial neoplasia and prostatic carcinoma].
BACKGROUND/AIM Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all proliferating cells. Index Ki-67 is considered to have prognostic significance. The aim of the study was ...
متن کاملHigh-Grade Prostatic Intraepithelial Neoplasia
High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. N...
متن کاملFrequency of high-grade prostatic intraepithelial neoplasia in Mexican population.
BACKGROUND High-grade intraepithelial neoplasia (HGPIN) is the only lesion regarded as precursor of prostatic carcinoma, though its frequency is unknown in many countries. Here we studied the frequency of HGPIN in a population with high grade frequency of prostatic carcinoma. MATERIAL AND METHODS A total of 486 cases of sextant prostatic biopsies performed from January 2001 to January 2006 we...
متن کاملPrevalence of high-grade prostatic intraepithelial neoplasia and its relationship to serum prostate specific antigen.
OBJECTIVE We assessed the incidence of high-grade prostatic intraepithelial neoplasia (HGPIN) in prostates removed for bladder cancer, and evaluated its correlation with preoperative serum prostate specific antigen (PSA). MATERIALS AND METHODS We reviewed the histology of the prostate from men who underwent cystoprostatectomy for bladder cancer without known prostate pathology prior to surger...
متن کاملDysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer.
PURPOSE To determine expression levels of annexin I (lipocortin I) in patient-matched benign prostatic epithelium (BPE), high-grade prostatic intraepithelial neoplasia (HGPIN), and prostate cancer (CaP). EXPERIMETNAL DESIGN: Annexin I protein expression was examined with a standard immunohistochemical protocol in 69 radical prostatectomy specimens, 45 of which also contained HGPIN. Immunostaine...
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ژورنال
عنوان ژورنال: Military Medical and Pharmaceutical Journal of Serbia
سال: 2007
ISSN: 0042-8450,2406-0720
DOI: 10.2298/vsp0705325j